The study investigated three patterns of negative affect due to precipitated naloxone withdrawal:
- Withdrawal following acute morphine treatment
- Withdrawal following constant chronic morphine treatment
- Withdrawal following increasing chronic morphine treatment
The team demonstrated that chronic morphine treatment was necessary to observe a deficit in social interaction and desper-like behaviour. In addition, all three models induced anxiety-like behaviour.
Overall, these models will contribute to the study of the behavioural and neural circuits involved in the various negative affective signs characterising opioid use disorders.
Source: Ozdemir D. et al. Model of negative affect induced by withdrawal from acute and chronic morphine administration in male mice. Scientific Reports 14, (2024). https://doi.org/10.1038/s41598-024-60759-3
Contact: Emmanuel Darcq, edarcq[at]unistra.fr
