Sleep disorders are well known in several neurodegenerative diseases, but remain little studied in the case of amyotrophic lateral sclerosis (ALS). In this new study, the authors focus on sleep changes and imbalances in hypothalamic signals in ALS patients. Using sleep recordings (polysomnography),…
This new publication by Scekic-Zahirovic et al. shows that cortical hyperexcitability is associated with early deficits in phase-amplitude theta-gamma coupling (PAC) and decreased noradrenaline (NA) in the motor cortex of ALS patients and in models. PAC deficits could be ameliorated by…
The mechanisms behind negative affect following opiate withdrawal precipitated by an antagonist such as naloxone are not well known. The Addictions team has therefore been looking into this issue, and recent work by Dersu OZDEMIR has enabled us to compare three different conditions.
This recent research shows that the loss of MCH+ hypothalamic neurons is linked to the metabolic problems that occur in ALS. Amyotrophic lateral sclerosis (ALS), also known as Charcot's disease, is a disease of the motor neurons (motoneurons), the nerve cells that control our muscles, and is the…
Work by Luc Dupuis' team has shown direct links between the genetics and anatomopathology of amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease). ALS is a disease of the motor neurons (motor neurons), the nerve cells that control our muscles, and is the most common disease in adults.
