Publications

2024

Simoes FA, Christoforidou E, Cassel R, Dupuis L, Hafezparast M. Severe dynein dysfunction in cholinergic neurons exacerbates ALS-like phenotypes in a new mouse model. Biochim Biophys Acta Mol Basis Dis. 2024 Oct 18;1871(1):167540. doi: 10.1016/j.bbadis.2024.167540. Epub ahead of print. PMID: 39428001.
Hernan-Godoy M, Rouaux C. From Environment to Gene Expression: Epigenetic Methylations and One-Carbon Metabolism in Amyotrophic Lateral Sclerosis. Cells. 2024 Jun 3;13(11):967. doi: 10.3390/cells13110967. PMID: 38891099; PMCID: PMC11171807.
Schuster J, Dreyhaupt J, Mönkemöller K, Dupuis L, Dieterlé S, Weishaupt JH, Kassubek J, Petri S, Meyer T, Grosskreutz J, Schrank B, Boentert M, Emmer A, Hermann A, Zeller D, Prudlo J, Winkler AS, Grehl T, Heneka MT, Johannesen S, Göricke B, Witzel S, Dorst J, Ludolph AC; RAS-ALS Study Group. In-depth analysis of data from the RAS-ALS study reveals new insights in rasagiline treatment for amyotrophic lateral sclerosis. Eur J Neurol. 2024 Apr;31(4):e16204. doi: 10.1111/ene.16204. Epub 2024 Jan 19. PMID: 38240416; PMCID: PMC11235627.
Jamet M, Dupuis L, Gonzalez De Aguilar JL. Oligodendrocytes in amyotrophic lateral sclerosis and frontotemporal dementia: the new players on stage. Front Mol Neurosci. 2024 Mar 22;17:1375330. doi: 10.3389/fnmol.2024.1375330. PMID: 38585368; PMCID: PMC10995329.
Scekic-Zahirovic J, Benetton C, Brunet A, Ye X, Logunov E, Douchamps V, Megat S, Andry V, Kan VWY, Stuart-Lopez G, Gilet J, Guillot SJ, Dirrig-Grosch S, Gorin C, Trombini M, Dieterle S, Sinniger J, Fischer M, René F, Gunes Z, Kessler P, Dupuis L, Pradat PF, Goumon Y, Goutagny R, Marchand-Pauvert V, Liebscher S, Rouaux C. Cortical hyperexcitability in mouse models and patients with amyotrophic lateral sclerosis is linked to noradrenaline deficiency. Sci Transl Med. 2024 Mar 13;16(738):eadg3665. doi: 10.1126/scitranslmed.adg3665. Epub 2024 Mar 13. PMID: 38478631.
Kodavati M, Wang H, Guo W, Mitra J, Hegde PM, Provasek V, Rao VHM, Vedula I, Zhang A, Mitra S, Tomkinson AE, Hamilton DJ, Van Den Bosch L, Hegde ML. FUS unveiled in mitochondrial DNA repair and targeted ligase-1 expression rescues repair-defects in FUS-linked motor neuron disease. Nat Commun. 2024 Mar 9;15(1):2156. doi: 10.1038/s41467-024-45978-6. PMID: 38461154; PMCID: PMC10925063.

2023

Nagel G, Kurz D, Peter RS, Rosenbohm A, Koenig W, Dupuis L, Bäzner H, Börtlein A, Dempewolf S, Schabet M, Hecht M, Kohler A, Opherk C, Naegele A, Sommer N, Lindner A, Tumani H, Ludolph AC, Rothenbacher D. Cystatin C based estimation of chronic kidney disease and amyotrophic lateral sclerosis in the ALS registry Swabia: associated risk and prognostic value. Sci Rep. 2023 Nov 10;13(1):19594. doi: 10.1038/s41598-023-46179-9. PMID: 37949878; PMCID: PMC10638424.
Shefner JM, Musaro A, Ngo ST, Lunetta C, Steyn FJ, Robitaille R, De Carvalho M, Rutkove S, Ludolph AC, Dupuis L. Skeletal muscle in amyotrophic lateral sclerosis. Brain. 2023 Nov 2;146(11):4425-4436. doi: 10.1093/brain/awad202. PMID: 37327376; PMCID: PMC10629757.
Provasek VE, Kodavati M, Guo W, Wang H, Boldogh I, Van Den Bosch L, Britz G, Hegde ML. lncRNA Sequencing Reveals Neurodegeneration-Associated FUS Mutations Alter Transcriptional Landscape of iPS Cells That Persists in Motor Neurons. Cells. 2023 Oct 16;12(20):2461. doi: 10.3390/cells12202461. PMID: 37887305; PMCID: PMC10604943.
Ludolph A, Dupuis L, Kasarskis E, Steyn F, Ngo S, McDermott C. Nutritional and metabolic factors in amyotrophic lateral sclerosis. Nat Rev Neurol. 2023 Sep;19(9):511-524. doi: 10.1038/s41582-023-00845-8. Epub 2023 Jul 27. PMID: 37500993.
Tzeplaeff L, Seguin J, Le Gras S, Megat S, Cosquer B, Plassard D, Dieterlé S, Paiva I, Picchiarelli G, Decraene C, Alcala-Vida R, Cassel JC, Merienne K, Dupuis L, Boutillier AL. Mutant FUS induces chromatin reorganization in the hippocampus and alters memory processes. Prog Neurobiol. 2023 Aug;227:102483. doi: 10.1016/j.pneurobio.2023.102483. Epub 2023 Jun 15. PMID: 37327984.
Bolborea M, Vercruysse P, Daria T, Reiners JC, Alami NO, Guillot SJ, Dieterlé S, Sinniger J, Scekic-Zahirovic J, Londo A, Arcay H, Goy MA, de Tapia CN, Thal DR, Shibuya K, Otani R, Arai K, Kuwabara S, Ludolph AC, Roselli F, Yilmazer-Hanke D, Dupuis L. Loss of hypothalamic MCH decreases food intake in amyotrophic lateral sclerosis. Acta Neuropathol. 2023 Jun;145(6):773-791. doi: 10.1007/s00401-023-02569-x. Epub 2023 Apr 14. PMID: 37058170; PMCID: PMC10175407.
Dorst J, Weydt P, Brenner D, Witzel S, Kandler K, Huss A, Herrmann C, Wiesenfarth M, Knehr A, Günther K, Müller K, Weishaupt JH, Prudlo J, Forsberg K, Andersen PM, Rosenbohm A, Schuster J, Roselli F, Dupuis L, Mayer B, Tumani H, Kassubek J, Ludolph AC. Metabolic alterations precede neurofilament changes in presymptomatic ALS gene carriers. EBioMedicine. 2023 Apr;90:104521. doi: 10.1016/j.ebiom.2023.104521. Epub 2023 Mar 12. PMID: 36917918; PMCID: PMC10024076.
Dupuis L, Chio A. The "metabolic axis" of ALS: The role of body weight in disease pathogenesis. Muscle Nerve. 2023 Mar;67(3):191-192. doi: 10.1002/mus.27784. Epub 2023 Jan 18. PMID: 36602891.
Di Pizio A, Marvaldi L, Birling MC, Okladnikov N, Dupuis L, Fainzilber M, Rishal I. A conditional null allele of Dync1h1 enables targeted analyses of dynein roles in neuronal length sensing. J Cell Sci. 2023 Mar 1;136(5):jcs260220. doi: 10.1242/jcs.260220. Epub 2022 Oct 31. PMID: 36218033; PMCID: PMC9687604.
Megat S, Mora N, Sanogo J, Roman O, Catanese A, Alami NO, Freischmidt A, Mingaj X, De Calbiac H, Muratet F, Dirrig-Grosch S, Dieterle S, Van Bakel N, Müller K, Sieverding K, Weishaupt J, Andersen PM, Weber M, Neuwirth C, Margelisch M, Sommacal A, Van Eijk KR, Veldink JH; Project Mine Als Sequencing Consortium; Lautrette G, Couratier P, Camuzat A, Le Ber I, Grassano M, Chio A, Boeckers T, Ludolph AC, Roselli F, Yilmazer-Hanke D, Millecamps S, Kabashi E, Storkebaum E, Sellier C, Dupuis L. Integrative genetic analysis illuminates ALS heritability and identifies risk genes. Nat Commun. 2023 Jan 20;14(1):342. doi: 10.1038/s41467-022-35724-1. Erratum in: Nat Commun. 2023 Dec 4;14(1):8026. doi: 10.1038/s41467-023-43710-4. PMID: 36670122; PMCID: PMC9860017.

2024

2023

Prix de la Fondation pour la Recherche Médicale

Subventions doctorales et financement de 4ème année de thèse

NeuroTechnologies INSERM

Officialisation de l'unité INSERM UMR-S 1329

Un nouveau pas dans la caractérisation des conséquences émotionnelles du sevrage aux opiacés

Défi Givré contre la SLA 2024

Modèle d'affect négatif induit par le sevrage après administration aiguë et chronique de morphine

Prix de thèse

Trouble du Déficit de l’Attention avec ou sans Hyperactivité (TDAH)

Une hormone hypothalamique liée à des dysrégulations métaboliques dans la SLA

Modèle d'affect négatif induit par le sevrage après administration aiguë et chronique de morphine

Une hormone hypothalamique liée à des dysrégulations métaboliques dans la SLA

Nouveaux gènes associés à la SLA